21 2025 INTEGRATED REPORT MARKET OVERVIEW Growth in life sciences is accelerating as leading pharmaceutical companies pursue major expansion initiatives, driven by rising demand for GLP‑1 weight‑loss therapies and increased investment in domestic manufacturing capacity across biologics, oncology, cell and gene therapies, and traditional pharmaceuticals. DELIVERY IN ACTION WHAT WE DELIVER For more than four decades, Fluor has delivered comprehensive services to life sciences clients – from emerging start-ups to fully integrated manufacturers – who produce essential products. Fluor delivers pharmaceutical manufacturing expertise across small molecule active pharmaceutical ingredients (APIs), peptides, oligonucleotides, biologics, plasma‑derived therapies, vaccines, and cell and gene therapies, supporting both bulk drug substance and drug product facilities for innovative pharmaceutical companies and contract and development manufacturing organizations. We have executed more than 1,400 projects across 30+ countries, including 75 facilities that account for more than three‑quarters of today’s global biotech sales. In 2025, Fluor continued to construct what will become North America’s largest pharmaceutical manufacturing facility. Capabilities at a Glance ` Single-point accountability for FDA-licensed facilities as well as European and other international standards, ensuring rapid time-to-market for critical launches ` Technical expertise in process design, including steady‑state simulation for continuous processes such as high‑vacuum solvent recovery ` Integrated process‑design expertise with innovative solutions for batch feed systems, reactor design, purification, and extraction Visit fluor.com to learn more about our life sciences expertise. Fluor completed construction on a confidential client’s biopharmaceutical project in January 2025. The facility’s expansion makes the site the largest end-to-end biopharmaceutical manufacturing facility in Europe and increases capacity from six to 12 mammalian cell culture bioreactors, which are used for the development and production of biological drugs, vaccines, and advanced therapies, ensuring life-changing medicines for patients around the world. EXPANDED BIOPHARMACEUTICAL PRODUCTION FACILITY Leadership and Governance Our Key Markets Our Impact Who We Are E P CM
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